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While progress has been made globally in reducing the impact of tuberculosis (TB), and while Australia has achieved a TB rate among the lowest reported, the South-East Asian region remains a global TB ‘hot spot’. Australia is well placed to help countries in our region deal with TB as we have world-class domestic systems for disease surveillance and control in human and animal health, and a strong track record of cooperation with countries in the region, including on primary health care. Research by a number of Australian research institutions has contributed to regional improvements to TB detection, prevention and treatment, and has demonstrated the possibility of the rapid reduction in TB prevalence within neighbouring countries.