Airborne pollen and respiratory allergies: Case Study 

NHMRC-funded researchers working nationally have helped to reduce the health and socioeconomic burden of pollen-related allergic respiratory diseases by improving the monitoring of airborne pollen and public access to information on local pollen levels. 

A poster version of this case study is available as a PDF from the Downloads section below. 

Origin 

In 1937, shortly after NHMRC was established, the Council received a letter from Charles Sutherland – an honorary physician at the Asthma Clinic at the Alfred Hospital in Melbourne – which contained suggestions for coordinating work on allergic diseases. Among other things, Sutherland suggested a survey of wind-borne pollens, a national collection of these pollens, and that observations be made on the incidence of pollen in the atmosphere in various localities at various seasons.³ 

A decade later, an NHMRC-funded survey of atmospheric pollen was conducted by researchers from The University of Western Australia. Pollen was counted daily, from July 1948 to December 1949, at 11 collecting stations located around metropolitan Perth. The survey found a close correlation between the amount of atmospheric pollen detected and the number of cases of hay fever observed at local hospitals.⁴ 

Despite these early beginnings and the high prevalence of allergic rhinitis in Australia,⁵ until recently, atmospheric pollen studies were conducted in isolation and limited to monitoring specific cities for narrow time periods. These studies did not use a standardised methodology designed for Australian conditions – since none existed – and nor was the resultant data combined to form a national picture.^6,7 

Grants and Investment 

NHMRC has supported the development of a standardised national pollen monitoring network through the AusPollen grant to Janet Davies, Bircan Erbas, Constance Katelaris, Edward Newbigin, Alfredo Huete, Elizabeth Ebert, Rieks van Klinken, Simon Haberle, Danielle Medek and Paul Beggs.  

NHMRC has also provided grants to another researcher involved in this work, Fay Johnston, who established the AirRater pollen and air quality service in Tasmania and the ACT. 

Other sources of funding include: Australian Research Council; Terrestrial Ecosystem Research Network (TERN - a National Collaborative Research Infrastructure Strategy facility), Allergy and Immunology Foundation of Australasia; Victorian Government Department of Health and Human Services, Tasmanian Department of Health, ACT Health, Queensland Health and Sense-T. 

Research 

As part of a research program looking at atmospheric particles and human health, Haberle, Johnston and colleagues monitored atmospheric pollen loads in Darwin (2004-2005) to generate the first pollen records for Darwin and tropical Australia.¹¹ A further study of atmospheric pollen loads in relation to public health was undertaken in Hobart, Tasmania (2007–2009).¹²  

These – and similar studies in Brisbane (1994-1999), Perth (2006), Sydney (1993-1995), Canberra (2007-2010), and Melbourne (2009-2011) – indicated a need to evaluate current knowledge of airborne pollen and led Davies to convene the Australian Aerobiology Working Group (AAWG) in 2013. 

The AAWG was supported by TERN’s Australian Centre for Ecological Analysis and Synthesis.⁶ Its task was to bring together medical professionals, botanists and climate change modellers – among others – to collate and analyse historical pollen count data and find innovative ways of making this data publicly accessible.¹³ The first AAWG study described the diversity of pollen records across Australia and New Zealand.⁷  

The group revealed the striking variation in the timing and level of airborne grass pollen between years and cities.¹⁴ This spatial and temporal variability in grass pollen exposures was related to latitude and, notably, secondary grass pollen peaks in summer and autumn extended the duration of pollen exposure nearer the equator.¹⁵  

The group were among the first globally to apply satellite remote sensing to show strong correspondence of grass pollen aerobiology with grass land vegetative indices, to enhance modelling of airborne grass pollen.¹⁶ 

These studies provided a framework for targeting grass pollens, some of the most clinically important due to their abundance, allergenic effects and public health impacts. 

Collaboration and Results  

Supported by NHMRC, in 2016 the AusPollen partnership was formed: led by Queensland University of Technology (QUT), involving eight academic institutes and co-developed with partner organisations; the Australasian Society of Clinical Immunology and Asthma (ASCIA), Asthma Australia, the Bureau of Meteorology, CSIRO, MeteoSwiss (Switzerland), Stallergenes Australia and AirRater. 

The goal of the partnership was to implement and evaluate standardized pollen monitoring practices and to extend evidence on Australian aerobiology and its health impacts nationally.  

Key outputs of the Partnership included: 

• the AusPollen Aerobiology Collaboration Network, with stations in Melbourne, Canberra, Sydney and Brisbane 
• the network’s Interim Standard and Protocols (ISP) – published as a health professional paper by ASCIA¹⁷ - that outlines minimum requirements and recommended best practice for all pollen monitoring processes  
• a standardised terms list of all pollen grains and fungal spores that are counted in Australia by pollen and spore monitoring sites affiliated with the network¹⁸ 
• newly established monitoring sites audited against the ISP, and assessment of the proficiency of pollen counters across the network¹⁹ 
• the development of websites and mobile device applications (apps) and their use to deliver pollen forecasting information to patients and clinicians²⁰ 
• the first continental scale, Southern Hemisphere standardized aerobiology dataset, to track shifts in the pollen seasons as well as health impacts²¹ 
• more accurate and evidence-based pollen forecasts, emphasising the importance of pollen monitoring data inputs to valid forecasts²²  
• evidence on why and how people use pollen information.²³ 

Outcomes and Impact 

The pollen-monitoring established by the partnership provides clinicians and respiratory allergy patients across Australia with accurate, up-to-date, standardised and localised information and forecasts on pollen levels. Access to pollen information via the pollen apps and websites increased from less than 1,000 users in 2012 to over 2 million during 2020.  

Davies and Katelaris collaborated with ASCIA, National Asthma Council and Asthma Australia to harmonise messages about the risks of pollen allergy in relation to asthma, including thunderstorm asthma. Their research informed a 2019 Federal Parliamentary Inquiry on Allergies and Anaphylaxis and they made multiple contributions to global clinical guidelines, policy, strategy and working parties that have helped to set direction for allergy research and practice internationally.²⁴ 

The AusPollen team played a key role during the 2016 thunderstorm asthma event and its recovery phase. Their research was awarded the European Academy for Allergy and Clinical Immunology Prize in 2016¹⁶ and informed forecast system development for the Bureau of Meteorology Victorian Thunderstorm Asthma Pollen Surveillance project in collaboration with Department of Health and Human Services. Newbigin, Lampugnani and others worked with the Bureau on the pilot thunderstorm asthma forecasting service that continues to operate in Victoria. 

Comparison of AusPollen data with previous records shows that grass pollen exposure in Queensland increased almost three-fold between the 1994-1999 and 2016-2020 monitoring periods. This was associated with climate factors.²⁶ Ongoing generation and sharing of pollen monitoring data can help inform management of people with allergies and track the effects of climate change on pollen exposure, especially in the context of extreme and La Nina weather.²⁷ 

Timeline 

*All grants listed are NHMRC grants unless stated otherwise

Researcher profiles 

Professor Janet Davies 

Janet Davies completed a PhD in Biology and Environmental Science at Murdoch University. Davies is Associate Dean of Research at QUT and Assistant Director of Research at Queensland’s Metro North Health, Australia's largest hospital network. 

Professor Bircan Erbas 

Bircan Erbas received a Masters degree in statistics and a PhD in biostatistics from The University of Melbourne (UoM) and is a professor at La Trobe University. Erbas is on the editorial board of Respirology and the International Journal of Environmental Research and Public Health. 

Professor Constance Katelaris 

Constance Katelaris is a Professor of Immunology and Allergy at UWS, is Head of Department and Senior Staff Specialist at Campbelltown Hospital, is past President of the Australasian Society of Clinical Immunology and Allergy and has monitored pollen in Sydney for many years. 

Associate Professor Edward Newbigin 

Edward Newbigin completed a PhD at ANU. He is an Associate Professor and a plant biologist in the School of BioSciences at UoM and has coordinated the Melbourne pollen count since 1998. 

Professor Simon Haberle 

Simon Haberle is Director of the School of Culture, History and Language at ANU, and has coordinated pollen monitoring in Canberra since 2004. Haberle held postdoctoral positions at the Smithsonian Tropical Research Institute (Panama) and the University of Cambridge. 

Associate Professor Paul Beggs 

Paul Beggs is Associate Professor in the School of Natural Sciences at Macquarie University. Beggs won the 2009 Australian Museum Eureka Prize for Medical Research and is Vice President of the International Association for Aerobiology. 

Distinguished Professor Alfredo Huete 

Alfredo Huete leads the Ecosystem Dynamics Health and Resilience Research Program at University of Technology Sydney (UTS). A geospatial ecologist, Huete has served on several international space program mission teams and conducted research in the Amazon as well global drylands. 

Dr Danielle Medek 

Danielle Medek completed a PhD in plant ecophysiology and a Bachelor of Medicine/Bachelor of Surgery at ANU. Medek was a Postdoctoral fellow at ANU and a Ziff Environmental Fellow at Harvard University and is a medical registrar at Queensland Health. 

Professor Fay Johnston 

Fay Johnston is Professor of Environmental Health at the Menzies Institute for Medical Research at the University of Tasmania (UTas). Johnston is a physician, environmental epidemiologist and a specialist medical advisor for Public Health Services in the Tasmanian Department of Health.  

Dr Edwin Lampugnani 

Edwin Lampugnani is a Senior Research Fellow in the School of BioScience at UoM. Lampugnani developed the digital frameworks used to deliver pollen information to the community and co-developed a pollen forecast model used by the Victorian thunderstorm asthma forecast service. 

Other researchers 

• Dr Elizabeth Ebert – Head, Forecast Quality Research, Bureau of Meteorology 
• Dr Penelope Jones – Menzies Institute for Medical Research, UTas  
• Dr Beth Addison Smith – Allergy Research Group, QUT 
• Dr Andelija Milic – Allergy Research Group, QUT 
• Dr Jeremy Silver – School of Earth Sciences, Faculty of Science, UoM 
• Dr Kathryn Emmerson – Atmospheric Composition and Chemistry group, CSIRO. 

References 

This case study was developed with input from Professor Janet Davies and in partnership with The Australian Pollen Allergen Partnership (AusPollen) team, The University of Tasmania’s AirRater team, Asthma Australia, The Bureau of Meteorology and the Australian Society for Clinical Immunology and Allergy. 

The information and images from which impact case studies are produced may be obtained from a number of sources including our case study partner, NHMRC’s internal records and publicly available materials. 

The following sources were consulted for this case study: 

1. Access Economics. The economic impact of allergic disease in Australia: not to be sneezed at. Report by Access Economics Pty Limited for the Australasian Society of Clinical Immunology and Allergy (ASCIA). 13 November 2007. Access Economics Pty Ltd
2. Erbas B, Jazayeri M, Lambert KA, Katelaris CH, Prendergast LA, Tham R, Parrodi MJ, Davies JM, Newbigin E, Abramson MJ, Dharmage SC. Outdoor pollen is a trigger of child and adolescent asthma ED presentations: a systematic review and meta-analysis Allergy. 2018; 73 1632-1641
3. National Health and Medical Research Council. Report of the National Health and Medical Research Council – Third Session. Held at Sydney, NSW, 12th and 13th November 1937. pp151-153. Canberra: NHMRC.
4. National Health and Medical Research Council. Report of the National Health and Medical Research Council – Twenty-Eighth Session. Held at Canberra, ACT, 16th and 17th November 1949. p87. Canberra: NHMRC
5. Australian Institute of Health and Welfare 2020. Allergic rhinitis ('hay fever'). Cat. no. PHE 257. Canberra: AIHW. Viewed 05 December 2020, https://www.aihw.gov.au/reports/chronic-respiratory-conditions/allergic-rhinitis-hay-fever. 
6. Davies JM, Beggs PJ, Medek DE, Newnham RM, Erbas B, Thibaudon M, Katelaris CH, Haberle SG, Newbigin EJ, Huete AR.  Trans-disciplinary synthesis of the impact of pollen aerobiology on health in Australasia Science of the Total Environment, 2015 354; 85–96. 
7. Haberle SG, Bowman DM, Newnham RM, Johnston FH, Beggs PJ, Buters J, Campbell B, Erbas B, Godwin I, Green BJ, Huete A. The macroecology of airborne pollen in Australian and New Zealand urban areas. PloS one. 2014 9;e97925.
8. Thien F, Beggs P, Csutoros D, Darvall J, Hew M, Davies JM, et al. The Melbourne epidemic thunderstorm asthma event 2016: a multidisciplinary investigation of environmental triggers, health service impact and patient risk factors. Lancet Planet Health 2018; 2: e255–63
9. Davies JM, Erbas E, Simunovic M, Al Kouba J, Milic A. 2017 “Literature review on thunderstorm asthma and implications for public health advice” available May 30 2017 https://www2.health.vic.gov.au/about/publications/researchandreports/thunderstorm-asthma-literature-review-may-2107
10. Inspector-General for Emergency Management. Review of response to the thunderstorm asthma event of 21-22 November 2016, Final Report. 2017. State of Victoria. p23
11. Stevenson J, Haberle SG, Johnston FH, Bowman DM. Seasonal distribution of pollen in the atmosphere of Darwin, tropical Australia: Preliminary results. Grana. 2007.46;34-42
12. Tng DY, Hopf F, Haberle SG, Bowman DM. Seasonal pollen distribution in the atmosphere of Hobart, Tasmania: preliminary observations and congruence with flowering phenology. Australian Journal of Botany. 2010.58;440-52.
13. TERN – Ecosystem Research Infrastructure. Relief in sight: countrywide pollen monitoring and mapping for early warning. News. December 2016. The University of Queensland. https://www.tern.org.au/relief-in-sight-countrywide-pollen-monitoring-and-mapping-for-early-warning/ Accessed 22 December 2021.
14. Beggs PJ, Katelaris CH, Medek D, Johnson FH, Burton PK, Campbell B, Jaggard AK, Vicendese D, Bowman DMJS, Godwin I, Huete A, Erbas B, Green, BJ, Newnham RM, Newbigin E, Haberle SG, Davies JM.  Differences in grass pollen allergen exposure across Australia.  Aust NZ J Public Health. 2015; 39:51-55
15. Medek DE, Beggs PJ, Erbas B, Jaggard AK, Campbell BC, Vicendese D, Johnson FH, Godwin I, Huete AR, Green BJ, Burton PK, Bowman DMJS, Newnham RM, Katelaris CH, Haberle SG, Newbigin E, Davies JM.  Regional and seasonal variation in airborne grass pollen levels between cities of Australia and New Zealand.  Aerobiologia, 2016; 32; 289-302.
16. Devadas R, Huete AR, Vicendese D, Erbas B, Beggs PJ, Medek D, Haberle SG, Newnham RM, Johnston FH, Jaggard AK, Campbell B. Dynamic ecological observations from satellites inform aerobiology of allergenic grass pollen. Science of the Total Environment. 2018. 633:441-51. 
17. Beggs PJ, Davies JM, Milic A, Haberle S G, Johnston F H, Jones P J, Katelaris CH, Newbigin E. (2018). Australian Airborne Pollen and Spore Monitoring Network Interim Standard and Protocols. https://www.allergy.org.au/hp/papers/australian-airborne-pollen-and-spore-monitoring-network-interim-standard-and-protocols. 
18. Milic A. Addison-Smith B, van Haeften S, Davies JM. Analysis of quality control outcomes of grass pollen identification and enumeration: experience matters., Aerobiologia 2021 37;797–808. 
19. Addison-Smith B, Wraith, D, Davies JM. Standardising pollen monitoring: quantifying confidence intervals for measurements of airborne pollen concentration. Aerobiologia 2020. 36;605–615 
20. Silver JD, Spriggs K, Haberle S, Katelaris CH, Newbiggin E, Lampugnani E. Crowd-sourced allergic rhinitis symptom data: The influence of environmental and demographic factors. Science Total Environment. 2020: 705; 135147
21. Davies JM, Addison-Smith B, Milic A, Campbell B, Van Haeften S, Burton P, Keaney B, Lampugnani ER, Vicendese D, Medek D, Huete A, Erbas B, Newbigin E, Katelaris CH, Haberle SG, Beggs PJ. The AusPollen partnership project: Allergenic airborne grass pollen seasonality and magnitude across temperate and subtropical eastern Australia, 2016–2020. Environ Res. 2022;214:113762
22. Emmerson KM, Addison-Smith E, Ebert E, Milic A, Vicendese D, Lampugnani ER, Erbas B, Medek DE, Huete A, Beggs P, Katelaris CH, Haberle SG, Newbigin E, Davies JM Evaluation of the performance of short-term curated daily airborne grass pollen forecasts in diverse biogeographical regions during the AusPollen Partnership project 2016–2020. Atmospheric Environment: X 15, October 2022, 100183
23. Medek DE, Simunovic M, Erbas B, Katelaris KH, Lampugnani ER, Huete A, Beggs PJ, Davies JM. Enabling self-management of pollen allergies: a pre-season questionnaire. a pre-season questionnaire evaluating the perceived benefit of providing local pollen information. Aerobiologia 2019. 35:777-782.
24. Bannister T, Ebert E, Silver J, Newbigin E, Lampugnani E, Csutoros D, Looker C, Mulvenna V, Jones P, Davies JM, Emmerson, K, Nguyen H, Huete A, Williams T, Wain A, Grant I, Carroll M, Beggs P, Suphioglu C. A pilot forecasting system for epidemic thunderstorm asthma in south-eastern Australia. Bull Am Met Society. 2020. 102: E399–E420.  
25. House of Representatives Standing Committee on Health, Aged Care and Sport. Walking the allergy tightrope: Addressing the rise of allergies and anaphylaxis in Australia. May 2020. Canberra
26. Addison-Smith,B, Milic A, Dwarakanath D, Simunovic M, van Haeften S, Timbrell V, Davies JM. Medium-Term Increases in Ambient Grass Pollen Between 1994-1999 and 2016-2020 in a Subtropical Climate Zone. Front. Allergy, 2021 2:705313
27. Commonwealth, Royal Commission into National Natural Disaster Arrangements, Report (2020)

Data outputs 

• https://data.aurin.org.au/dataset/auspollen-rocklea-qld-6168c420545c70ad5962f414-na 
• https://data.aurin.org.au/dataset/auspollen-canberra-act-6168c4209b7c5111055ffa84-na 
• https://data.aurin.org.au/dataset/auspollen-parkville-vic-6168c42016eb4e98d9b8cb28-na 
• https://data.aurin.org.au/dataset/auspollen-campbelltown-nsw-6168c4200e772c4de5849e89-na 
• https://www.nationalasthma.org.au/living-with-asthma/resources/health-professionals/information-paper/thunderstorm-asthma

Links to other information: 

• https://auspollen.edu.au/auspollensitesmap/
• https://www.allergy.org.au/images/ASCIA_PCC_Pollen_allergy_2020.pdf
• https://www.allergy.org.au/patients/allergic-rhinitis-hay-fever-and-sinusitis
• https://www.nationalasthma.org.au/living-with-asthma/resources/health-professionals/information-paper/thunderstorm-asthma
• https://www.allergy.org.au/hp/papers/australian-airborne-pollen-and-spore-monitoring-network-interim-standard-and-protocols 

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