NHMRC opened a Targeted Call for Research (TCR) into Myalgic Encephalomyelitis/ Chronic Fatigue Syndrome (ME/CFS) on 23 October 2019. Applications closed on 29 January 2020.

The development of this TCR was guided by the Myalgic Encephalomyelitis/ Chronic Fatigue Syndrome (ME/CFS) Advisory Committee established by the NHMRC.

The intended aims of this TCR were to:

  • Develop a scientifically valid, evidence-based understanding of the pathophysiology and aetiology of ME/CFS and the way it impacts on the physical, social and psychological wellbeing of affected persons.
  • Identify approaches that will assist patients presenting with symptoms of ME/CFS to be accurately diagnosed, including the identification potential biomarkers to facilitate effective management and treatment.
  • Cultivate interdisciplinary research collaboration, both locally and internationally.

Applications received during the call were peer reviewed by an expert panel. Following peer review, 3 applications were funded by NHMRC. Details of the awarded grants are provided in the Funding outcomes table.

Table: Funding outcomes
App IDChief Investigator AApplication TitleAdministering InstitutionBudgetGrant duration
APP1199363Professor Ken WalderUsing ‘omics to unravel the pathophysiology and repurpose drugs to treat ME/CFS Deakin University$1,083,010.002020-2025 
APP1199502Professor Sonya Marshall-GradisnikIon channel dysfunction in the pathophysiology of Myalgic Encephalomyelitis/ Chronic Fatigue Syndrome: diagnostic biomarkers, therapeutic targets and treatmentsGriffith University$1,460,700.002021-2025
APP1200292Professor Paul GooleyExploring the role of nitrogen metabolism, energy metabolism and mitochondrial function in the pathophysiological mechanisms of paediatric ME/CFSUniversity of Melbourne$784,063.502020-2023